Composition : Skelofen 10 : Baclofen USP 10 mg tablet.
Indications : ♦ Spasm of skeletal muscle ♦ Reflex muscle contractions ♦ Spasticity resulting from multiple sclerosis, spinal cord injuries and other spinal cord diseases ♦ Muscle spasm of cerebral origin especially infantile cerebral palsy ♦ Indirect effects of treatment with Skelofen include, improvement of sleep patterns, improvement in bladder and sphincter function and helps in the prevention and healing of decubitus ulcers
♦ Cerebrovascular accidents or neoplastic or degenerative brain disease ♦ Tension-type headache.
Dosage & Administration : 3 times daily for adults and 4 times daily for children.
Adults : Start therapy at low dosage and increase gradually until optimum effect is achieved (usually between 30 – 80 mg daily).
The following dosage titration schedule is suggested :
5 mg three times a day for 3 days
10 mg three times a day for 3 days
Thereafter additional increases may be necessary, but the total daily dose should usually not be exceeded a maximum of 80 mg, although in hospitalized patients, daily doses of 100 – 120 mg may occasionally be given.
Children : Treatment should be started at a very low dose e.g. 0.3 mg / kg per day in divided doses. The dosage should be raised cautiously at 1 – 2 week intervals until it is sufficient for the child’s individual needs. The usual dosage range for maintenance therapy is 0.75 to 2 mg / kg body weight per day. In children, aged over 10 years, a maximum daily dose of 2.5mg / kg bodyweight may be given.